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BIBTEX RIS

Formation of Dimethylmuconolactones from Dimethylphenols by Alcaligenes eutrophus JMP 134

1995; American Society for Microbiology; Volume: 61; Issue: 6 Linguagem: Inglês

10.1128/aem.61.6.2159-2165.1995

ISSN

1098-5336

Autores

D H Pieper, Karin Stadler-Fritzsche, Hans-Joachim Knackmuß, K. N. Timmis,

Tópico(s)

Microbial Natural Products and Biosynthesis

Resumo

2,3-, 2,4-, 2,5-, 3,4-, and 3,5-dimethylphenols were cometabolized by 2,4-dichlorophenoxyacetate-grown Alcaligenes eutrophus JMP 134 or the constitutive derivative JMP 134-1 via the ortho pathway into dimethylmuconolactones as dead-end products. Formation of two distinct lactones from 3,4-dimethylphenol is indicative of 2- as well as 6-hydroxylation. Induction of the meta-cleavage pathway by 2,3- and 3,4-dimethylphenols resulted in growth and no accumulation of products. In contrast, 3,5-dimethylphenol is not metabolized by the meta-cleavage pathway.

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