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Second-line chemotherapy in advanced pancreatic carcinoma: a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the FOLFOX4 regimen in clinical practice

2007; Elsevier BV; Volume: 18; Linguagem: Inglês

10.1093/annonc/mdm240

1569-8041

Vittorio Gebbia, Evaristo Maiello, Francesco Giuliani, Nicolò Borsellino, Michele Caruso, G. Di Maggio, Francesco Ferraù, Roberto Bordonaro, Francesco Verderame, Paolo Tralongo, L. Di Cristina, R. Agueli, Patrizia Russo, Giuseppe Colucci,

Cancer Genomics and Diagnostics

Background: In daily clinical practice second-line chemotherapy (SLCT) is frequently given to patients with advanced pancreatic cancer failing gemcitabine-based first-line chemotherapy without solid scientific support.Patients and methods: A retrospective survey was carried out including 42 patients.Patients received standard FOLFOX4 regimen biweekly until progression or unacceptable toxicity.Results: Six partial responses (14%) and 16 stabilizations (38%) were recorded for a tumor growth control rate of 57%.The median time to progression (TtP) was 4 months (range 1-7 months), and median overall survival (OS) was 6.7 months (range 2-9 months).A stabilization of performance status (PS) and a subjective improvement of cancer-related symptoms were recorded in 27 patients.Conclusions: Data presented in this paper support the use of FOLFOX4 regimen in the second-line treatment of adenocarcinoma of the pancreas patients.The use of SLCT, however, should be carefully proposed to patients with good PS or those who had a good response to first-line therapy.