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Macrovascular disease in a Japanese–Brazilian population of high prevalence of metabolic syndrome: Associations with classical and non-classical risk factors

2006; Elsevier BV; Volume: 195; Issue: 1 Linguagem: Inglês

10.1016/j.atherosclerosis.2006.09.012

1879-1484

Antonela F.A. Siqueira, Laércio Joel Franco, Suely G.A. Gimeno, Luiza K. Matsumura, Dulcinéia Saes Parra Abdalla, Newton de Barros, Sandra Roberta G. Ferreira,

Lipoproteins and Cardiovascular Health

Abstract Background The Japanese–Brazilian Diabetes Study detected high prevalence of metabolic syndrome (MS) in a population of Japanese ancestry living in Brazil. We describe the prevalence of macrovascular disease (MVD) and its association with classical and non-classical cardiovascular risk factors in this population. Methods An overall of 1163 individuals were studied; diagnosis of MVD was based on a score obtained from medical history, ankle-brachial pressure index and electrocardiogram, defining three groups: no MVD, possible MVD and definite MVD. Results Prevalence of MVD was 14.3% (possible MVD: 11.2%; definite MVD: 3.1%). Individuals with MS had higher rates of MVD (16.9% versus 11.2%; p <0.05). Comparing to no MVD, age, 2h plasma glucose, anti-LDL(+) and anti-LDL(−) levels, and urinary albumin-to-creatinine ratio were higher in both categories with MVD; waist-to-hip ratio, fasting plasma glucose, HbA1c, total-to-HDL cholesterol ratio and triglycerides were higher in that with definite MVD; systolic blood pressure and homocysteine were higher in that with possible MVD. Using logistic regression, systolic blood pressure, smoking habit and anti-LDL(+) were independently associated with MVD. Conclusion MVD is highly prevalent in Japanese–Brazilians and its association with MS was confirmed. A novel marker of lipoprotein modifications – anti-LDL(+) antibody – could be useful in identifying individuals at higher risk.