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Revisado por pares
Unusual Chromophore and Cross‐Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog
2008; Wiley; Volume: 47; Issue: 41 Linguagem: Inglês
10.1002/anie.200802901
ISSN1521-3773
AutoresM. Oke, Rosalind Tan Yan Ching, Lester G. Carter, Kenneth A. Johnson, Huanting Liu, S.A. McMahon, Malcolm F. White, Carlos Bloch, Catherine H. Botting, Martin Walsh, Aishah A. Latiff, Malcolm W. Kennedy, Alan Cooper, James H. Naismith,
Tópico(s)Enzyme Structure and Function
ResumoAngewandte Chemie International EditionVolume 47, Issue 41 p. 7853-7856 Communication Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog† Muse Oke Dr., Muse Oke Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229 These authors contributed equally to this work.Search for more papers by this authorRosalind Tan Yan Ching Dr., Rosalind Tan Yan Ching Dr. WestChem Department of Chemistry, University of Glasgow, Glasgow G12 8QQ (UK), Fax: (+44) 141-330-2910 These authors contributed equally to this work.Search for more papers by this authorLester G. Carter Dr., Lester G. Carter Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorKenneth A. Johnson Dr., Kenneth A. Johnson Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorHuanting Liu Dr., Huanting Liu Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorStephen A. McMahon Dr., Stephen A. McMahon Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorMalcolm F. White Prof., Malcolm F. White Prof. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorCarlos Bloch Jr. Dr., Carlos Bloch Jr. Dr. Embrapa Recursos Genéticos e Biotecnologia, Parque Estação Biológica, Asa Norte–Brasilia, 70910-900 (Brazil)Search for more papers by this authorCatherine H. Botting Dr., Catherine H. Botting Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorMartin A. Walsh Dr., Martin A. Walsh Dr. Medical Research Council France, European Synchrotron Radiation Facility, F-38043, Grenoble CEDEX (France)Search for more papers by this authorAishah A. Latiff Prof., Aishah A. Latiff Prof. Doping Control Centre Penang, Universiti Sains Malaysia, 11800 Minden, Penang (Malaysia)Search for more papers by this authorMalcolm W. Kennedy Prof., Malcolm W. Kennedy Prof. Division of Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ (UK)Search for more papers by this authorAlan Cooper Prof., Alan Cooper Prof. alanc@chem.gla.ac.uk WestChem Department of Chemistry, University of Glasgow, Glasgow G12 8QQ (UK), Fax: (+44) 141-330-2910Search for more papers by this authorJames H. Naismith Prof., James H. Naismith Prof. naismith@st-and.ac.uk Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this author Muse Oke Dr., Muse Oke Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229 These authors contributed equally to this work.Search for more papers by this authorRosalind Tan Yan Ching Dr., Rosalind Tan Yan Ching Dr. WestChem Department of Chemistry, University of Glasgow, Glasgow G12 8QQ (UK), Fax: (+44) 141-330-2910 These authors contributed equally to this work.Search for more papers by this authorLester G. Carter Dr., Lester G. Carter Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorKenneth A. Johnson Dr., Kenneth A. Johnson Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorHuanting Liu Dr., Huanting Liu Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorStephen A. McMahon Dr., Stephen A. McMahon Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorMalcolm F. White Prof., Malcolm F. White Prof. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorCarlos Bloch Jr. Dr., Carlos Bloch Jr. Dr. Embrapa Recursos Genéticos e Biotecnologia, Parque Estação Biológica, Asa Norte–Brasilia, 70910-900 (Brazil)Search for more papers by this authorCatherine H. Botting Dr., Catherine H. Botting Dr. Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this authorMartin A. Walsh Dr., Martin A. Walsh Dr. Medical Research Council France, European Synchrotron Radiation Facility, F-38043, Grenoble CEDEX (France)Search for more papers by this authorAishah A. Latiff Prof., Aishah A. Latiff Prof. Doping Control Centre Penang, Universiti Sains Malaysia, 11800 Minden, Penang (Malaysia)Search for more papers by this authorMalcolm W. Kennedy Prof., Malcolm W. Kennedy Prof. Division of Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ (UK)Search for more papers by this authorAlan Cooper Prof., Alan Cooper Prof. alanc@chem.gla.ac.uk WestChem Department of Chemistry, University of Glasgow, Glasgow G12 8QQ (UK), Fax: (+44) 141-330-2910Search for more papers by this authorJames H. Naismith Prof., James H. Naismith Prof. naismith@st-and.ac.uk Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, The University, St Andrews KY16 9ST (UK), Fax: (+44) 1334-467-229Search for more papers by this author First published: 24 September 2008 https://doi.org/10.1002/anie.200802901Citations: 16 † We thank the BBSRC, the Wellcome Trust, and the Scottish Higher Education Funding Council (SHEFC) for financial support and Dr. Neeta Sinnappah, Jeet Sukamaran, Norsham Yaakob, Aw Ai Fong, Lim Ming Sang, and Lim Tau Chin for help with fieldwork and sample collection. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A smurfin' good structure: The 1.16 Å resolution crystal structure of ranasmurfin, a blue protein extracted from the foam nests of the Malaysian tree frog Polypedates leucomystax, reveals unusual posttranslational chemical modifications. The chromophore involves an extended Zn-coordinated four-residue (Lys-Tyr-Tyr-Lys) inter-subunit cross-link of a kind not previously reported. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802901_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume47, Issue41September 29, 2008Pages 7853-7856 RelatedInformation
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