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Properties of Mechano-Transduction via Simulated Microgravity and its Effects on Intracellular Trafficking of VEGFR's

2012; Impact Journals LLC; Volume: 3; Issue: 4 Linguagem: Inglês

10.18632/oncotarget.472

1949-2553

Andrew Puca, Giuseppe Russo, Antonio Giordano,

Hedgehog Signaling Pathway Studies

Andrew Puca 1 , Giuseppe Russo 1 and Antonio Giordano 1,2 1 Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University Philadelphia, PA USA 2 Department of Human Pathology and Oncology, University of Siena, Nuovo Policlinico "Le Scotte", Siena, Italy Received: March 29, 2012, Accepted: May 5, 2012, Published: May 6, 2012, Keywords: Thrombopoietin, VEGFR's, CD34+, CD45 Correspondence: Antonio Giordano, email: // // Abstract This study emphasizes the dynamical properties of mechanical loading via simulated microgravity, its effect on acute myeloid leukemia proliferation and hematopoietic stem cell (HSPC) growth and its implications in the area of tissue regeneration. Data presented illustrates that mechanical transduction changes the expression of humoral factors by facilitating paracrine/autocrine signalling, therefore modulating intracellular trafficking of tyrosine kinase receptors. Understanding mechano-transduction in the context of cell and tissue morphogenesis is the major focus of this study. The effects of external physiological stresses, such as blood flow, on several cellular subtypes seem to produce very intricate cellular responses. It is well accepted that mechanical loading plays an intrinsic and extrinsic influence on cell survival. This study shows how microgravity effects hematopoietic stem cells, and human leukemic cell proliferation and expression of its receptors that control cell survival, such as the tyrosine kinase vascular endothelial growth factor receptor-1, receptor-2 and receptor-3.