Artigo Revisado por pares

Nonpeptide glycoprotein IIb/IIIa inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation

1997; Elsevier BV; Volume: 7; Issue: 21 Linguagem: Inglês

10.1016/s0960-894x(97)10085-3

ISSN

1464-3405

Autores

Karen M. Brashear, Jacquelynn J. Cook, Bohumil Bednář, Rodney A. Bednar, Robert J. Gould, Wasyl Halczenko, Marie A. Holahan, Robert J. Lynch, George D. Hartman, John H. Hutchinson,

Tópico(s)

Monoclonal and Polyclonal Antibodies Research

Resumo

The structure-activity relationship (SAR) of a series of orally active glycoprotein IIb/IIIa antagonists containing an alkyl or aryl sulfonamide grafted onto an indole core is described.

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