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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit (Oxalidaceae: Geraniales)

2005; Elsevier BV; Volume: 46; Issue: 7 Linguagem: Inglês

10.1016/j.neuint.2005.02.002

ISSN

1872-9754

Autores

Ruither Oliveira Gomes Carolino, Renê Oliveira Beleboni, Ângela A Pizzo, Fabrizio Vecchio, Norberto Garcia‐Cairasco, Miguel Moysés Neto, Wagner Ferreira dos Santos, Joaquim Coutinho‐Netto,

Tópico(s)

Medicinal Plants and Neuroprotection

Resumo

We obtained a neurotoxic fraction (AcTx) from star fruit (Averrhoa carambola) and studied its effects on GABAergic and glutamatergic transmission systems. AcTx had no effect on GABA/glutamate uptake or release, or on glutamate binding. However, it specifically inhibited GABA binding in a concentration-dependent manner (IC50 = 0.89 μM). Video-electroencephalogram recordings demonstrated that following cortical administration of AcTx, animals showed behavioral changes, including tonic-clonic seizures, evolving into status epilepticus, accompanied by cortical epileptiform activity. Chemical characterization of AcTx showed that this compound is a nonproteic molecule with a molecular weight less than 500, differing from oxalic acid. This neurotoxic fraction of star fruit may be considered a new tool for neurochemical and neuroethological research.

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