A Role for the Roof Plate and Its Resident TGFβ-Related Proteins in Neuronal Patterning in the Dorsal Spinal Cord
1997; Cell Press; Volume: 91; Issue: 1 Linguagem: Inglês
10.1016/s0092-8674(01)80015-5
ISSN1097-4172
AutoresKarel F. Liem, Gabi Tremml, Thomas M. Jessell,
Tópico(s)TGF-β signaling in diseases
ResumoDistinct neuronal cell types are generated at characteristic times and positions in the dorsal horn of the spinal cord. We provide evidence that the identity and pattern of generation of dorsal neurons depend initially on BMP-mediated signals that derive from the epidermal ectoderm and induce dorsal midline cells of the roof plate. Roof plate cells provide a secondary source of TGFβ-related signals that are required for the generation of distinct classes of dorsal interneurons. These inductive interactions involve both qualitative and quantitative differences in signaling by TGFβ-related factors and temporal changes in the response of neural progenitor cells.
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