Inadvertent diagnosis of male infertility through genealogical DNA testing
2005; BMJ; Volume: 42; Issue: 4 Linguagem: Inglês
10.1136/jmg.2004.023796
ISSN1468-6244
Autores Tópico(s)Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Resumo2 many companies also offer to deduce ''ancestry''. As the number of markers used in these tests increases, so does the probability of inadvertently diagnosing male infertility through the detec- tion of Y chromosomal deletions. Using commercially typed Y markers, we here report the ascertainment of such deletions in general population samples. METHODS Samples were collected with informed consent and relevant ethical approval from the Leicestershire Research Ethics Committee (ref. 5796) and the Committee for Scientific Investigations in Greenland (ref. 505-16). Deletion analysis was carried out using standard PCR techniques; primer sequences and conditions are given in original references cited for markers in the text below.
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