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Meteoritic C α ‐Methylated α‐Amino Acids and the Homochirality of Life: Searching for a Link

2004; Wiley; Volume: 43; Issue: 48 Linguagem: Inglês

10.1002/anie.200460908

1521-3773

Marco Crisma, Alessandro Moretto, Fernando Formaggio, Bernard Kaptein, Quirinus B. Broxterman, Claudio Toniolo,

Protein Structure and Dynamics

Angewandte Chemie International EditionVolume 43, Issue 48 p. 6695-6699 Communication Meteoritic Cα-Methylated α-Amino Acids and the Homochirality of Life: Searching for a Link Marco Crisma Dr., Marco Crisma Dr. Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this authorAlessandro Moretto Dr., Alessandro Moretto Dr. Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this authorFernando Formaggio Prof., Fernando Formaggio Prof. Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this authorBernard Kaptein Dr., Bernard Kaptein Dr. DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The NetherlandsSearch for more papers by this authorQuirinus B. Broxterman Dr., Quirinus B. Broxterman Dr. DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The NetherlandsSearch for more papers by this authorClaudio Toniolo Prof., Claudio Toniolo Prof. claudio.toniolo@unipd.it Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this author Marco Crisma Dr., Marco Crisma Dr. Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this authorAlessandro Moretto Dr., Alessandro Moretto Dr. Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this authorFernando Formaggio Prof., Fernando Formaggio Prof. Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this authorBernard Kaptein Dr., Bernard Kaptein Dr. DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The NetherlandsSearch for more papers by this authorQuirinus B. Broxterman Dr., Quirinus B. Broxterman Dr. DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The NetherlandsSearch for more papers by this authorClaudio Toniolo Prof., Claudio Toniolo Prof. claudio.toniolo@unipd.it Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239Search for more papers by this author First published: 09 December 2004 https://doi.org/10.1002/anie.200460908Citations: 25Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Catch a falling star: Peptides from chiral, Cα-methylated α-amino acids (see scheme) found in L enantiomeric excess in meteorites show diastereoselectivity when reacting with racemic proteinogenic amino acids. Accordingly, the prebiotic soup of proteinogenic amino acids may have evolved into a chirally unbalanced system, eventually seeding the homochirality of life. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460908_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume43, Issue48December 10, 2004Pages 6695-6699 RelatedInformation