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Biologically active glycosides from asteroidea, XXXII. Glycosphingolipids from the starfish Astropecten latespinosus , 2. Structure of two new ganglioside molecular species and biological activity of the ganglioside

1995; Wiley; Volume: 1995; Issue: 3 Linguagem: Inglês

10.1002/jlac.199519950374

0947-3440

Ryuichi Higuchi, S. Matsumoto, Masanori Fujita, Tetsuya Komori, Takuma Sasaki,

ATP Synthase and ATPases Research

Abstract Two ganglioside molecular species [LG‐1 ( 1 ) and LG‐2 ( 5 )] have been obtained from the water‐soluble lipid fraction of the chloroform/methanol extract of the starfish Astropecten latespinosus . On the basis of chemical and spectroscopic findings, the structure of 1 and 5 have been elucidated. They are new ganglioside molecular species. Negative FAB mass spectrometry provided important information both on the structure of the sugar moiety and on the molecular mass of the gangliosides. Partial hydrolysis by hot water has proved useful for structure elucidation of the complex oligosaccharide moieties. In addition, the major ganglioside molecular species, LG‐2 ( 5 ), shows antitumor activity against murine lymphoma L1210 cells in vitro.