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Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum

1993; American Society for Microbiology; Volume: 61; Issue: 1 Linguagem: Inglês

10.1128/iai.61.1.268-273.1993

1098-5522

Palle Jakobsen, Lars Hviid, Thor G. Theander, E A Afare, Robert G. Ridley, Peter M. H. Heegaard, Dietrich Stüber, K. Dalsgaard, Francis Nkrumah,

Vibrio bacteria research studies

The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.