Voltar
Revisão Acesso aberto Revisado por pares
BIBTEX RIS

Schizophrenia in Translation: Is Active Psychosis Neurotoxic?

2005; Oxford University Press; Volume: 32; Issue: 4 Linguagem: Inglês

10.1093/schbul/sbl032

ISSN

1745-1701

Autores

Thomas H. McGlashan,

Tópico(s)

Ion channel regulation and function

Resumo

Positive symptoms of psychosis disrupt mentation. Do they also engineer brain cell death and deterioration? This hypothesis is currently popular as an explanation of the duration of untreated psychosis effect in early schizophrenia. The clinical and neurobiological evidence for its validity is visited and found wanting. Synaptic plasticity, not neurotoxicity, appears to be the mediating process.

Referência(s)