Orbital Interactions in Strong and Weak Hydrogen Bonds are Essential for DNA Replication We thank the National Research School Combination—Catalysis (NRSCC) for a postdoctoral fellowship for C.F.G. and the National Computer Facilities (NCF) foundation of the Netherlands Organization for Scientific Research (NWO) for financial support.
2002; Wiley; Volume: 41; Issue: 12 Linguagem: Inglês
10.1002/1521-3773(20020617)41
ISSN1521-3773
AutoresCélia Fonseca Guerra, F. Matthias Bickelhaupt,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoNot only the shape of the bases, but also the orbital interactions in the hydrogen bonds are essential for DNA replication, as follows from quantum-chemical analyses of Watson–Crick pairs and mimics thereof (see Figure: X, Z=O, F, H; W, Y=N, C), in combination with earlier experimental results.
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