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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma

2002; Oxford University Press; Volume: 33; Issue: 3 Linguagem: Inglês

10.1111/j.1574-695x.2002.tb00588.x

ISSN

1574-695X

Autores

Abdussalam Ali Ramadan Ashour, Paula P. Magalhães, Edilberto Nogueira Mendes, Guilherme Birchal Collares, Valquíria R. Gusmão, Dulciene Maria Magalhães Queiroz, Ana Margarida Miguel Ferreira Nogueira, Gifone Aguiar Rocha, Celso Affonso de Oliveira,

Tópico(s)

Gastric Cancer Management and Outcomes

Resumo

This PCR-based analysis is the first molecular epidemiological study in Brazil testing Helicobacter pylori cagA and vacA distribution in adults with gastric complaints, that includes a large number of carcinoma patients. Multiple-strain infection was identified in 11/13.4% patients. vacA s1-m1 and cagA+ genotypes were the most common in patients with a non-mixed infection. All vacA s1 strains were s1b, so subtyping s1 strains was not useful. vacA s1b-m1 and cagA+ strains were associated with higher prevalence of peptic ulcer and gastric carcinoma than vacA s2-m2 and cagA− ones. In conclusion, cagA and vacA genotyping may have clinical relevance in Brazil.

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