HLAreporter: a tool for HLA typing from next generation sequencing data
2015; BioMed Central; Volume: 7; Issue: 1 Linguagem: Inglês
10.1186/s13073-015-0145-3
ISSN1756-994X
AutoresYazhi Huang, Jing Yang, Dingge Ying, Yan Zhang, Vorasuk Shotelersuk, Nattiya Hirankarn, Pak C. Sham, YL Lau, Wanling Yang,
Tópico(s)Complement system in diseases
ResumoHuman leukocyte antigen (HLA) typing from next generation sequencing (NGS) data has the potential for widespread applications.Here we introduce a novel tool (HLAreporter) for HLA typing from NGS data based on read-mapping using a comprehensive reference panel containing all known HLA alleles, followed by de novo assembly of the gene-specific short reads.Accurate HLA typing at high-digit resolution was achieved when it was tested on publicly available NGS data, outperforming other newly developed tools such as HLAminer and PHLAT.
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