Portal de Periódicos da CAPES

Antidesmocollin-1 antibody–positive, antidesmoglein antibody–negative pemphigus herpetiformis

2010; Elsevier BV; Volume: 63; Issue: 1 Linguagem: Inglês

10.1016/j.jaad.2009.09.016

1097-6787

Chiharu Tateishi, Daisuke Tsuruta, Takeshi Nakanishi, Shinji Uehara, Hiromi Kobayashi, Masamitsu Ishii, Takashi Hashimoto,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

To the Editor: Pemphigus is an autoimmune skin disease that is divided into two major subtypes—pemphigus vulgaris (PV) and pemphigus foliaceus (PF).1 Pemphigus herpetiformis (PH) is recognized as a distinct variant of pemphigus by its pruritus, rarity of mucosal involvement, histologically eosinophilic spongiosis, and good response to sulfones. Clinical characteristics of PH include erythematous papules and plaques with occasional vesicles in a herpetiform arrangement.2 The major target antigens of PH are desmogleins (Dsg) 1 and 3, the targets for PF and PV, respectively.2 We present a case of PH with immunoglobulin G (IgG) autoantibodies to desmocollin (Dsc) 1 but without antibodies to Dsgs.