Portal de Periódicos da CAPES

Nutzung von Paraffinen und anderen Nichtkohlenhydrat‐Kohlenstoffquellen zur mikrobiellen Citronensäuresynthese

1982; Akademie-Verlag; Volume: 22; Issue: 6 Linguagem: Inglês

10.1002/jobm.19820220608

0044-2208

U. Stottmeister, U. Behrens, E. Weißbrodt, Gerold Barth, D. Franke‐Rinker, Ernst‐Detlef Schulze,

Enzyme Structure and Function

Abstract This article reviews the developments achieved in citrate and isocitrate accumulation with non‐carbohydrate substrates by microorganisms presented as well in academic publications as in patents. The efficiency of citrate and isocitrate overproducing microorganisms and of mutants obtained thereof with respect to different carbon sources ( n ‐alkanes, triglycerides, organic acids, etc .) is discussed. The influence of environmental conditions (media, pH etc .) and biochemical mechanisms which lead to metabolic overflow are emphasized. The kinetics of fermentation processes are discribed, calculations concerning carbon balances are involved. The production of by‐products and the conversion of isocitrate to citrate is considered. The production of citric acid by yeasts which utilize different carbon sources may be economically feasible and an accession to the practized molasse‐ Aspergillus ‐process.