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Lipoic Acid and N-acetyl Cysteine Decrease Mitochondrial-Related Oxidative Stress in Alzheimer Disease Patient Fibroblasts

2007; IOS Press; Volume: 12; Issue: 2 Linguagem: Inglês

10.3233/jad-2007-12210

1875-8908

Paula I. Moreira, Peggy L.R. Harris, Xiongwei Zhu, Maria S. Santos, Catarina R. Oliveira, Mark A. Smith, George Perry,

Tryptophan and brain disorders

In this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, Nε -(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzh