Revisão Acesso aberto Revisado por pares

The genetic basis of reproductive isolation: Insights from Drosophila

2005; National Academy of Sciences; Volume: 102; Issue: suppl_1 Linguagem: Inglês

10.1073/pnas.0501893102

ISSN

1091-6490

Autores

H. Allen Orr,

Tópico(s)

Evolution and Genetic Dynamics

Resumo

Recent studies of the genetics of speciation in Drosophila have focused on two problems: ( i ) identifying and characterizing the genes that cause reproductive isolation, and ( ii ) determining the evolutionary forces that drove the divergence of these “speciation genes.” Here, I review this work. I conclude that speciation genes correspond to ordinary loci having normal functions within species. These genes fall into several functional classes, although a role in transcriptional regulation could prove particularly common. More important, speciation genes are typically very rapidly evolving, and this divergence is often driven by positive Darwinian selection. Finally, I review recent work in Drosophila pseudoobscura on the possible role of meiotic drive in the evolution of the genes that cause postzygotic isolation.

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