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Polymorphism of Repeated Regions of Pertactin in Bordetella pertussis , Bordetella parapertussis , and Bordetella bronchiseptica

2000; American Society for Microbiology; Volume: 68; Issue: 8 Linguagem: Inglês

10.1128/iai.68.8.4815-4817.2000

1098-5522

Caroline Boursaux‐Eude, Nicole Guiso,

Escherichia coli research studies

ABSTRACT Pertactin is an outer membrane protein expressed by Bordetella pertussis , Bordetella parapertussis , and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.