Portal de Periódicos da CAPES

Skin cancer induction by UV radiation: molecular UV targets and quantitative risk models

2004; Springer Nature (Netherlands); Linguagem: Inglês

10.1007/978-94-017-0511-0_11

1568-2595

Frank R. de Gruijl, Harry Slaper,

Cutaneous Melanoma Detection and Management

Cancer research is making great strides in the fundamental understanding of how a normal cell can turn malignant, i.e., proliferate and spread uncontrollably. The relevant changes (carcinogenic “events”) that lead to cancer can be detected or even quantified in terms of frequency of occurrence. In animal experiments on UV-induced skin cancers, the relation between such early carcinogenic events and wavelength, exposure and lapse of time can be studied in great detail. Epidemiology revealed the importance of solar (UV) exposure in the etiology of human skin cancer (see Chapters 5, 6) and early carcinogenic events can, in principle, also be detected in humans. Quantitative risk models can be refined and improved by integrating these experimental and epidemiological data. Such refined and detailed quantitative models are, however, in their infancy.