The <i>In vivo</i> Effects of Caffeine on the Hypoglycemic Activity of Gliclazide and Metformin in Healthy Rats
1970; Volume: 8; Issue: 1 Linguagem: Inglês
10.3329/dujps.v8i1.5335
ISSN1816-1839
AutoresMuhammad M. Mohiuddin, Md. Shah Amran, Md Amjad Hossain,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoAn in vivo study has been conducted to observe the effects of caffeine on the hypoglycemic activity ofgliclazide and metformin HCI in rats. For this, healthy rats weighing about 250±25 g were used and the blood sugarlevels were measured after administration of a drug alone and in combination. Diabetes was induced in rats byadministration of alloxan at a dose of 40 mg/kg body weight. Drugs were administered in rats and were observed forfour weeks. The blood sugar levels were estimated in two stages; firstly, after two week and secondly, after four weekof administration of drug. It was found that the hypoglycemic activities of both gliclazide and metformin HCl werepotentiated by concurrent application of caffeine and either of the drugs, but the extent of potentiation was more incase of metformin HCI as evident from the blood sugar level of rats.Key words: Caffeine; Gliclazide; Metformin; Diabetes; Alloxan; Blood sugar; Rats.DOI: 10.3329/dujps.v8i1.5335Dhaka Univ. J. Pharm. Sci. 8(1): 47-51, 2009 (June)
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