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HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis

2005; Associação Brasileira de Divulgação Científica; Volume: 38; Issue: 5 Linguagem: Inglês

10.1590/s0100-879x2005000500015

1414-431X

André Castro Lyra, João Renato Rebello Pinho, Luciano Kalabric Silva, Lívia Feitosa de Sousa, Cláudia Patara Saraceni, Eduardo Lorens Braga, Júlio Eduardo Gomes Pereira, Maria Alice Sant'Anna Zarife, Mitermayer Galvão dos Reis, Luiz Guilherme Costa Lyra, L.C. da Silva, Flair José Carrilho,

Viral gastroenteritis research and epidemiology

The aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as controls. IgM and anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial kits. TTV and GBV-C/HGV were detected by nested PCR; genotyping was done by sequencing and phylogenetic analysis. Anti-HEV IgG was present in 38, 10 and 17% of patients with hepatitis A, B and non-A-C. Four patients with hepatitis A and 1 with non-A-C hepatitis also had anti-HEV IgM detected in serum. TTV was detected in 21% of patients with acute hepatitis and in 31% of donors. GBV-C/HGV was detected in 9% of patients with hepatitis, and in 10% of donors. We found TTV isolates of genotypes 1, 2, 3, and 4 and GBV-C/HGV isolates of genotypes 1 and 2. Mean aminotransferase levels were lower in patients who were TTV or GBV-C/HGV positive. In conclusion, the detection of anti-HEV IgM in some acute hepatitis A cases suggests co-infection with HEV and hepatitis E could be the etiology of a few cases of sporadic non-A-C hepatitis in Salvador, Brazil. TTV genotype 1, 2, 3 and 4 isolates and GBV-C/HGV genotype 1 and 2 strains are frequent in the studied population. TTV and GBV-C/HGV infection does not appear to have a role in the etiology of acute hepatitis.