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Transcriptional Regulation and Its Misregulation in Disease

2013; Cell Press; Volume: 152; Issue: 6 Linguagem: Inglês

10.1016/j.cell.2013.02.014

1097-4172

Tong Ihn Lee, Richard A. Young,

Cancer-related gene regulation

The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease. The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.