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Post-hypoxic early selective putaminal necrosis followed by delayed extensive sub-cortical demyelination

2007; Taylor & Francis; Volume: 21; Issue: 11 Linguagem: Inglês

10.1080/02699050701633056

1362-301X

Vijay K. Sharma, June H. Tan,

Traumatic Brain Injury Research

Objective: To describe the patterns of early and delayed hypoxic damage to the brain parenchyma.Methods: This paper reports a case with interesting clinical course and MRI brain changes in a patient following a single hypoxic-anoxic exposure after an alcoholic binge.Results: Bilaterally symmetrical putaminal necrosis was noted in the initial MRI, but subsequent follow-up revealed extensive demyelination of the sub-cortical white matter, associated with the clinical deterioration.Conclusions: The brain, in general, and the neurons in caudate nucleus, putamen, globus pallidus and cerebral white matter, in particular, are susceptible to hypoxic injury. These changes may occur simultaneously and early or sequentially and late.