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Recent Syntheses and Biological Activity of Lentiginosine and its Analogues

2014; Bentham Science Publishers; Volume: 14; Issue: 10 Linguagem: Inglês

10.2174/1568026614666140423113226

1873-4294

Franca M. Cordero, Donatella Giomi, Alberto Brandi,

Carbohydrate Chemistry and Synthesis

(+)-Lentiginosine, a natural trans-1,2-dihydroxyindolizidine belonging to the class of iminosugars, is a potent inhibitor of amyloglucosidase, and a good inhibitor of Hsp90. The non-natural enantiomer, (–)-lentiginosine, induces apoptosis on tumor cells of different origin and is poorly cytotoxic towards non-transformed cells. The significant biological activity of these compounds has resulted in the development of many synthetic approaches for their preparation. This review is an update of a previous survey and summarizes the most recent achievements on biological studies as well as total syntheses of lentiginosine and trans-1,2-dihydroxyindolizidine analogues. Keywords: Alkaloids, apoptosis, azaheterocycles, glycosidase inhibitors, hydroxyindolizidines, iminosugars, organic syntheses.