The choice of a balanced allocation method for a clinical trial in otitis media with effusion
1990; Wiley; Volume: 9; Issue: 3 Linguagem: Inglês
10.1002/sim.4780090306
ISSN1097-0258
AutoresG. A. Zielhuis, Huub Straatman, A. E. Van 'T Hof‐Grootenboer, Henk J.J. van Lier, G. H. Rach, Paul van den Broek,
Tópico(s)Speech and Audio Processing
ResumoAbstract We review the choice of treatment allocation procedures in a specific small clinical trial of the effect of tympanostomy tubes on language development in patients with otitis media with effusion. The options for balanced allocation available at the planning stage are discussed. A clearly favourable method could not be identified. A simulation study was performed, and its results demonstrated least imbalance with the variance method. In practice this method produced considerable imbalance on relevant prognostic factors.
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