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Revisão Produção Nacional Revisado por pares

BIBTEX RIS

Insulinoma diagnosed in the postpartum: clinical and immunohistochemical features

2012; Informa; Volume: 28; Issue: 8 Linguagem: Inglês

10.3109/09513590.2011.650756

1473-0766

Amadeu José Rodrigues Queiróz, Larissa Simões Nazareno, Jane Eyre Miranda, Ana Emília Borges de Azevedo, Carlos Augusto Teixeira da Cruz, Fabiana Pirani Carneiro, A. C. F. Costa, Adriana Lofrano‐Porto,

Pancreatic and Hepatic Oncology Research

Insulinomas are rare pancreatic β-cell tumors with an estimated incidence of 1:250.000 persons/year. We present a novel case of insulinoma manifesting immediately after childbirth. Eight days after delivery, a 21-year-old, previously healthy woman presented paresthesia in hands, upper and lower limbs muscle weakness with difficult walking, which worsened during breastfeeding sessions. Laboratory tests showed blood glucose levels between 37 and 55 mg/dL with inappropriately normal insulin levels (7.78 μUI/mL; normal range: 5–29). An abdominal computed tomography showed a nodular lesion measuring 2 cm at the head of the pancreas. Tumor enucleation resulted in complete resolution of hypoglycemia. Histopathological and immunohistochemical analysis were consistent with an insulinoma. About 27 cases of insulinoma associated with pregnancy have been reported to date, mostly diagnosed before the 16th week. The beginning of symptoms soon after delivery is less common. Understanding the interactions between pancreatic β-cell function and all the physiological metabolic and hormonal adaptations associated with gestation is essential for the adequate management of hypoglycemic disorders in pregnant women.