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Antinociceptive activity of discretamine isolated from Duguetia moricandiana

2011; Taylor & Francis; Volume: 25; Issue: 20 Linguagem: Inglês

10.1080/14786419.2010.491227

1478-6427

Jackson Roberto Guedes da Silva Almeida, Julianeli Tolentino de Lima, Henrique Ribeiro de Oliveira, Marianna Ribeiro De Oliveira, Paulo Roberto Marinho Meira, Ana Sílvia Suassuna Carneiro Lúcio, José Maria Barbosa‐Filho, Lucindo José Quintans‐Júnior,

Chemical synthesis and alkaloids

The phytochemical study of Duguetia moricandiana Mart. (Annonaceae) yielded the isolation of the alkaloid which was identified by spectral analysis as discretamine. The evaluation of antinociceptive activity carried out by the acetic acid-induced writhing, formalin and hot plate tests in mice, suggests a potent antinociceptive effect. Discretamine (5, 10 and 20 mg kg⁻¹, i.p.) significantly reduced the number of writhes similarly at all doses tested and the number of paw licks during the first phase of formalin test when compared to control. The effect of discretamine on hot plate response provides a confirmation of its central effect. These results indicate antinociceptive properties of this alkaloid.