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Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

2005; Elsevier BV; Volume: 15; Issue: 14 Linguagem: Inglês

10.1016/j.bmcl.2005.05.044

1464-3405

Eduarda M. P. Silva, Francesca Giuntini, M. Amparo F. Faustino, João P. C. Tomé, Maria G. P. M. S. Neves, Augusto C. Tomé, Artur M. S. Silva, M.G. Santana-Marques, A. J. Ferrer‐Correia, José A. S. Cavaleiro, Maria Filomena Caeiro, Ricardo R. Duarte, Sabina A.P. Tavares, Inês N. Pegado, Bruno d’Almeida, António Matos, Maria Luísa Valdeira,

Nanoplatforms for cancer theranostics

An easy route to cationic β-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.