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Interaction between Platinum Complexes and a Methionine Motif Found in Copper Transport Proteins

2007; Wiley; Volume: 46; Issue: 47 Linguagem: Inglês

10.1002/anie.200703271

1521-3773

Fabio Arnesano, Simone Scintilla, Giovanni Natile,

Drug Transport and Resistance Mechanisms

Going to the Mets: The uptake of Pt anticancer drugs also involves the Cu transporter Ctr1, which is located on the plasma membrane and contains functionally essential methionine-rich motifs. The methionine-rich peptide Mets7 reacts readily with PtII species. A striking difference between cis- and trans-[PtCl2(NH3)2] is that, upon reaction with Mets7, only the latter retains its N-donor ligands. Delivery of undegraded Pt drug to intracellular organelles by vesicle trafficking is hypothesized.