Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens
1997; American Society for Microbiology; Volume: 41; Issue: 12 Linguagem: Inglês
10.1128/aac.41.12.2776
ISSN1098-6596
AutoresBetsy C. Herold, Alicia M. Siston, James W. Bremer, Risa Kirkpatrick, George D. Wilbanks, Péter Fügedi, Csaba J. Peto, M D Cooper,
Tópico(s)Immune Response and Inflammation
ResumoHeparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.
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