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Periodontal disease: a new factor associated with the presence of multiple complex coronary lesions

2011; Wiley; Volume: 39; Issue: 1 Linguagem: Inglês

10.1111/j.1600-051x.2011.01802.x

1600-051X

Christine Romagna, Laurie Soulat-Dufour, O. Troisgros, Luc Lorgis, Carole Richard, Philippe Buffet, Gilles Soulat, Jean-Marie Casillas, Gilles Rioufol, Claude Touzery, Marianne Zeller, Yves Laurent, Yves Cottin,

Infective Endocarditis Diagnosis and Management

Periodontal disease, including bone loss, is thought to be involved in coronary artery disease. Multiple complex coronary lesions relate to multifocal destabilization of coronary plaques. We investigated whether bone loss could be associated with the presence of multiple complex coronary lesions.This cross-sectional study included 150 patients with recent myocardial infarction ( 50% was performed. Patients with no or simple complex lesions were compared to patients with multiple complex lesions.Over 20% of patients had multiple complex coronary lesions. Patients with multiple complex lesion were less likely to be women and more likely to have multivessel disease or elevated C-reactive protein (CRP) than patients with no or single complex lesion. Bone loss >50% tended to be more frequent in patients with multiple complex lesions (p = 0.063). In multivariate analysis, multivessel disease, gender and CRP were associated with multiple complex lesion. Bone loss >50% increased the risk of multiple complex lesion.Bone loss was associated with complex multiple coronary lesions, beyond systemic inflammation. These findings may bear important clinical implications for the prevention and treatment of coronary artery disease.