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Asymmetries and Visual Field Summaries as Predictors of Glaucoma in the Ocular Hypertension Treatment Study

2006; Cadmus Press; Volume: 47; Issue: 9 Linguagem: Inglês

10.1167/iovs.05-0469

1552-5783

Richard A. Levine, Shaban Demirel, Juanjuan Fan, John L. Keltner, Chris A. Johnson, Michael A. Kass, Donald L. Budenz, Francisco Fantes, Steven J. Gedde, Richard Parrish, Madeline L. Del Calvo, Thomas S. Harbin, Paul E. McManus, Charles J. Patorgis, M. L. Hooper, Stacey S. Goldstein, Debbie L. Lee, L.H.G. Morton, Marianne L. Perry, Teresa A. Long, S. R. Smith, Julie Wright, Ronald L. Gross, Silvia Orengo-Nania, Pamela M. Frady, Benita D. Slight, George A. Cioffi, Annisa L. Jamil, Steven L. Mansberger, Emily Patterson, Kathryn R. Sherman, Jo Anne M Fraser, A. Beck, A P Costarides, Camilele M. Hylton, Donna Leef, Nauman R. Imami, Deborah Darnley-Fisch, Aldo Fantin, Melanie Gutkowski, Elizabeth Carnegie, Sheila M. Rock, Donald J. Zack, Donald A. Abrams, Nathan Congdon, Robert A. Copeland, David S. Friedman, Ramzi Hemady, Eve J. Higginbotham, Henry Jampel, Irvin P. Pollack, Harry A. Quigley, Alan L. Robin, Rachel A. Scott, Felicia Keel, Lisa A. Levin, Kevin L. Powdrill, Robyn Priest-Reed, Anne L. Coleman, Richard S. Baker, Yadavinder Dang, Jo Ann A Giaconi, Simon K. Law, Bobbie Ballenberg, Salvador Murillo, Manju Sharma, Terry J. Bergstrom, Christina A. Bruno, Sayoko E. Moroi, Carol J. Pollack-Rundle, Michelle A. Tehranisa, Bret A. Hughes, Monica Y. Allen, Mark S. Juzych, Mark L. McDermott, John M. Ramocki, J G Allen, Laura L. Schulz, John M. O'Grady, Linda A. Van Conett, Mary Beth Hall, Joern B. Soltau, J. Mohay, Robb R. Shrader, Sandy Lear, David C. Herman, Douglas H. Johnson, Becky A. Nielsen, Nancy J. Tvedt, Jeffrey M. Liebmann, Robert Ritch, Celso Tello, Jean L. Walker, Nina Mondoc, Deborah L. Simon, Paul A. Weber, N. Douglas Baker, Robert J. Derick, David M. Lehmann, Kathyrne McKinney, Diane Moore, George Bennett, Myron Yanoff, Lindsay C. Bennett, Mary Jameson, Jody R. Piltz‐Seymour, Hina N. Ahmed, Eydie Miller, Prithvi S. Sankar, Cheryl McGill, Janice Petner, James D. Brandt, Jeffrey J. Casper, Michele C. Lim, Ivan R. Schwab, Ingrid J. Clark, Denise M. Owensby, Marilyn A. Sponzo, Robert N. Weinreb, J. Rigby Slight, Osaro A. Okuonghae, Michael V Drake, Allan J. Flach, Shan C. Lin, Robert L. Stamper, Fermin P. Ballesteros, Valerie Margol, Kathleen A. Lamping, Cheryl L. Vitelli, Bettina J. Modica, Douglas Gaasterland, Robin L. Montgomery, Frank S. Ashburn, Karen D. Schacht, Arthur L. Schwartz, Howard S. Weiss, Clete Clark, Anne M. Boeckl, Edward M. Barnett, Bernard Becker, Anjali M. Bhorade, Allan E. Kolker, Carla J. Siegfried, Sandra Quirin, Fortunata Darmody, D. R. Anderson, Donald F. Everett, Mae E. Gordon, Dale K. Heuer, John A. Keltner, M. Roy Wilson, Patricia A. Morris, Teresa A. Roediger, John Connett, Claude L. Cowan, Barry R. Davis, Joanne Katz, Ronald Munson, Mark B. Sherwood, Gregory L. Skuta, Dale K. Heur, Steven Kymes, J. Philip Miller, Mary Bednarski, Julia A. Beiser, Karen Clark, Betsy Hornbeck, E Long, Deborah A. Dunn, Maria Cristina Wells-Albornoz, Ruth Vandenbroucke, Heather L. Johnson, William J. Feuer, Joyce Schiffman, Ditte J. Hess, Kimberly E. Cello, Shannan E. Bandermann, Bhupinder S. Dhillon, Linda M. Zangwill, Keri Dirkes, Pamela A. Sample, William M. Bourne,

Ocular Surface and Contact Lens

To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants.A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants.The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD.The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.