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Comparing the Compressibility of Ludipress with the Other Direct Tableting Agents by Using Acetaminophen as an Active Ingredient

1991; Taylor & Francis; Volume: 17; Issue: 17 Linguagem: Inglês

10.3109/03639049109048080

1520-5762

Tamer Baykara, Gülengül Duman, K. Ş. Özşener, Şefıka ORDU, Betül ÖZATEŞ,

Pharmacy and Medical Practices

AbstractLudipress is a direct tableting agent which acts as an unique component, is really a multi component. In this study Ludipress compressibility and powder technological properties are compared with the other kind of DC agents (Avicel PH 102, Elcema G 250 and Elcema P 050) which are structurally based on cellulose. Acetaminophen has been chosen as an active ingredient.The compression properties of powders and three direct tableting agent were investigated using the Heckel and Kawakita equations. Each formulations and compressed tablets which are compacted by hydraulic press with different pressure value were photographed by scanning electron microscope.As a result Ludipress shows stable flow properties and the dilution potential of Ludipress is lower than the other DC agents.