Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
2014; American Association for the Advancement of Science; Volume: 6; Issue: 261 Linguagem: Inglês
10.1126/scitranslmed.3009835
ISSN1946-6242
AutoresYang Yu, Jasvinder K. Atwal, Yin Zhang, Raymond K. Tong, Kristin R. Wildsmith, Christine Tan, Nga Bien‐Ly, Maria Hersom, Janice Maloney, William J. Meilandt, Daniela Bumbaca, Kapil Gadkar, Kwame Hoyte, Wilman Luk, Yanmei Lu, James A. Ernst, Kimberly Scearce‐Levie, Jessica A. Couch, Mark S. Dennis, Ryan J. Watts,
Tópico(s)Protein purification and stability
ResumoBispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β-amyloid.
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