Revisão Revisado por pares

How gene expression in fast‐proliferating cells keeps pace

2015; Wiley; Volume: 37; Issue: 5 Linguagem: Inglês

10.1002/bies.201400195

ISSN

1521-1878

Autores

Rui Gonçalo Martinho, Leonardo G. Guilgur, Pedro Prudêncio,

Tópico(s)

Genomics and Chromatin Dynamics

Resumo

The development of living organisms requires a precise coordination of all basic cellular processes, in space and time. Early embryogenesis of most species with externally deposited eggs starts with a series of extremely fast cleavage cycles. These divisions have a strong influence on gene expression as mitosis represses transcription and pre‐mRNA processing. In this review, we will describe the distinct adaptations for efficient gene expression and discuss the emerging role of the multifunctional NineTeen Complex (NTC) in gene expression and genomic stability during fast proliferation.

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