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BIBTEX RIS

Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

2006; Multidisciplinary Digital Publishing Institute; Volume: 4; Issue: 1 Linguagem: Inglês

10.3390/md401001

ISSN

1660-3397

Autores

Jaine Honorata Hortolan Luiz, Mirna Helena Regali Seleghim, Christoph Timm, Achim Grube, Matthias Köck, Gislene G. F. Nascimento, Ana Claudia T. Martins, Elissa G. O. Silva, Ana Olı́via de Souza, Paulo Roberto Regazi Minarini, Fábio C. S. Galetti, Célio Lopes Silva, Eduardo Hajdu, Roberto G. S. Berlinck,

Tópico(s)

Microbial Natural Products and Biosynthesis

Resumo

Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines.

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