Portal de Periódicos da CAPES

Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development

2010; American Association for the Advancement of Science; Volume: 2; Issue: 26 Linguagem: Inglês

10.1126/scitranslmed.3000251

1946-6242

Adam M Gustafson, Raffaella Soldi, Christina Anderlind, Mary Beth Scholand, Jun Qian, Xiaohui Zhang, Kendal G. Cooper, Darren Walker, Annette McWilliams, Gang Liu, Éva Szabó, Jerome S. Brody, Pierre P. Massion, Marc E. Lenburg, Stephen Lam, Andrea Bild, Avrum Spira,

Cytokine Signaling Pathways and Interactions

A cancer-associated signaling pathway is reversibly activated in the normal airways of smokers before they develop lung cancer, presenting an opportunity for preventive therapy.