Produção Nacional
Revisado por pares
HPV 18 prevalence in oral mucosa diagnosed with verrucous leukoplakia: cytological and molecular analysis
2012; BMJ; Volume: 65; Issue: 8 Linguagem: Inglês
10.1136/jclinpath-2012-200673
ISSN1472-4146
AutoresJulio Cesar Betiol, Sérgio Kignel, Willys Tristão, Ana Carolina Arruda, Sabrina Katy Souza Santos, Renata Barbieri, Jussara de Sousa Ribeiro Bettini,
Tópico(s)Cervical Cancer and HPV Research
ResumoCurrently more than 200 types of human papillomaviruses (HPV) have been classified, where the low-risk ones are those that are not capable of developing into cancer while the high-risk ones are.1 Cervical cancer and its preceding lesions have been strongly associated with HPV, mainly through the high-risk 16/18 strains. Due to morphological similarities between the cervical mucosa and the upper aerodigestive tract, it is suggested that HPV be proposed as an aetiological factor in the developing of oral cancer.2 In 1978, WHO defined leukoplakia as a white plaque of oral mucosa, not removable by scraping, which cannot be characterised clinically or pathologically as any other disorder.3 Recent publications have grouped leukoplakia with lesions that precede oral cancer or those that are potentially malignant.4 HPV's role in the aetiology and malignisation of precancerous oral lesions has been studied; however, the results achieved are still not conclusive. The purpose of this study was to identify the prevalence of HPV 16/18 in patients with verrucous leukoplakia of the oral mucosa, along with a profile of their social demographics. ### Obtaining samples The UNIARARAS community, located in Araras, Sao Paulo, Brazil, was divided in two groups: …
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