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The face of rejection: Rejection sensitivity moderates dorsal anterior cingulate activity to disapproving facial expressions

2007; Taylor & Francis; Volume: 2; Issue: 3-4 Linguagem: Inglês

10.1080/17470910701391711

1747-0927

Lisa J. Burklund, Naomi I. Eisenberger, Matthew D. Lieberman,

Pain Management and Placebo Effect

Abstract Abstract Previous research has examined neural responses to threatening facial expressions such as those displaying anger, fear, and disgust. Here, we examined neural responses to a different type of threatening facial expression that primarily signifies a threat to social connection, namely a “disapproving” facial expression. We hypothesized that neural responses to disapproving facial expressions would be moderated by individual differences in rejection sensitivity. Using functional magnetic resonance imaging (fMRI), we scanned participants while they viewed brief video clips of facial expressions depicting disapproval, anger, and disgust. As expected, all three expressions yielded bilateral amygdala activation relative to a resting baseline. Additionally, individuals who scored higher on a measure of rejection sensitivity exhibited greater dorsal anterior cingulate cortex activity in response to disapproving facial expressions, but not in response to anger or disgust facial expressions. Results suggest that, at the neural level, individuals high in rejection sensitivity may be more sensitive to facial expressions signaling potential rejection, but not to threatening facial expressions in general. Results also suggest that disapproving facial expressions convey a distinct type of threat and should be considered in future studies of socially threatening facial expressions. Acknowledgements This research was supported by a National Institutes of Mental Health (NIMH) postdoctoral research fellowship (T32MH-019925) to NIE, a UCLA Health Psychology Program university graduate fellowship to LJB, a predoctoral research fellowship from NIMH to LJB as part of the UCLA Health Psychology Program (MH15750), and an NIMH grant to MDL (MH071521). We also appreciate the support provided by the Brain Mapping Medical Research Organization, Brain Mapping Support Foundation, Pierson-Lovelace Foundation, the Ahmanson Foundation, Tamkin Foundation, Jennifer Jones-Simon Foundation, Capital Group Companies Charitable Foundation, Robson Family, William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation, Northstar Fund, and National Center for Research Resources grants RR12169, RR13642 and RR08655.