Dysautonomia and heart rate variability following severe traumatic brain injury
2006; Taylor & Francis; Volume: 20; Issue: 4 Linguagem: Inglês
10.1080/02699050600664715
ISSN1362-301X
AutoresIan Baguley, Roxana Heriseanu, Kim L. Felmingham, Ian D. Cameron,
Tópico(s)Psychosomatic Disorders and Their Treatments
ResumoPrimary objective: To investigate disconnection theories postulated as the cause of dysautonomia following severe traumatic brain injury (TBI) through analysis of heart rate variability (HRV).Methods and procedures: Data were collected on age-matched subjects with and without dysautonomia (eight subjects in each group) and 16 non-injured controls. Data included injury details, continuous electrocardiograph recordings and rehabilitation outcome.Main outcomes and results: The TBI group revealed significant differences in HRV parameters both compared to controls and between dysautonomic and non-dysautonomic subjects. Additionally, HRV parameters for dysautonomic subjects showed evidence of an uncoupling of the normal relationship between heart rate and sympathetic/parasympathetic balance. HRV changes persisted for the dysautonomia group for a mean of 14 months post-injury.Conclusions: Dysautonomic subjects revealed prolonged uncoupling of heart rate and HRV parameters compared to non-dysautonomic subjects and controls. These findings represent direct pathophysiological evidence supporting the disconnection theory postulated to produce dysautonomia following TBI.
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