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BIBTEX RIS

MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

2008; BioMed Central; Volume: 5; Issue: 1 Linguagem: Inglês

10.1186/1742-4690-5-118

ISSN

1742-4690

Autores

Laurent Houzet, Man Lung Yeung, Valéry de Lame, Dhara Desai, Stephen M. Smith, Kuan‐Teh Jeang,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

Abstract MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.

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