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Cell Cycle Genes in Ovarian Cancer

2004; American Association for Cancer Research; Volume: 10; Issue: 24 Linguagem: Inglês

10.1158/1078-0432.ccr-04-0886

1557-3265

Giuseppina D’Andrilli, C. S. V. Satish Kumar, Giovanni Scambia, Antonio Giordano,

Epigenetics and DNA Methylation

Abstract Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell cycle-regulatory mechanisms. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes that display a range of abnormalities with potential usefulness as markers of evolution or treatment response in ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to divide cell cycle-regulatory genes into four subgroups on the basis of their predominant role in a specific phase or during the transition between two phases of the cell cycle.