The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation
2003; Elsevier BV; Volume: 120; Issue: 4 Linguagem: Inglês
10.1016/s0925-4773(03)00004-2
ISSN1872-6356
AutoresBeate Kilian, Hannu Mansukoski, Filipa Carreira de Avelar Barbosa, Florian Ulrich, Masazumi Tada, Carl‐Philipp Heisenberg,
Tópico(s)Developmental Biology and Gene Regulation
ResumoWnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements.
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