A Direct Method for Site‐Specific Protein Acetylation
2011; Wiley; Volume: 50; Issue: 41 Linguagem: Inglês
10.1002/anie.201103754
ISSN1521-3773
AutoresFupeng Li, Abdollah Allahverdi, Renliang Yang, Gavian Bing Jia Lua, Xiao‐Hong Zhang, Yuan Cao, Nikolay Korolev, Lars Nordenskiöld, Chuan‐Fa Liu,
Tópico(s)Peptidase Inhibition and Analysis
ResumoAngewandte Chemie International EditionVolume 50, Issue 41 p. 9611-9614 Communication A Direct Method for Site-Specific Protein Acetylation† Fupeng Li, Fupeng Li Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorAbdollah Allahverdi, Abdollah Allahverdi Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorRenliang Yang, Renliang Yang Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorGavian Bing Jia Lua, Gavian Bing Jia Lua Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorDr. Xiaohong Zhang, Dr. Xiaohong Zhang Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorYuan Cao, Yuan Cao Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorDr. Nikolay Korolev, Dr. Nikolay Korolev Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorProf. Lars Nordenskiöld, Prof. Lars Nordenskiöld Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorProf. Chuan-Fa Liu, Corresponding Author Prof. Chuan-Fa Liu cfliu@ntu.edu.sg Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this author Fupeng Li, Fupeng Li Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorAbdollah Allahverdi, Abdollah Allahverdi Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorRenliang Yang, Renliang Yang Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorGavian Bing Jia Lua, Gavian Bing Jia Lua Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorDr. Xiaohong Zhang, Dr. Xiaohong Zhang Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorYuan Cao, Yuan Cao Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorDr. Nikolay Korolev, Dr. Nikolay Korolev Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorProf. Lars Nordenskiöld, Prof. Lars Nordenskiöld Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this authorProf. Chuan-Fa Liu, Corresponding Author Prof. Chuan-Fa Liu cfliu@ntu.edu.sg Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Divisions of Chemical Biology and Biotechnology and of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551 (Singapore)Search for more papers by this author First published: 16 September 2011 https://doi.org/10.1002/anie.201103754Citations: 105 † This work is supported by grants from A*Star (C.F.L.) and Ministry of Education (L.N.) of Singapore. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Radicals at work: Radical-mediated thiol-ene addition of the thiol group of Cys to N-vinylacetamide gives acetyl-thialysine (KSAc), a near-perfect mimic of acetyl-lysine (see picture). The reaction is highly efficient with near quantitative conversion obtained in short reaction times. The generated KSAc is functionally identical or similar to its native counterpart. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201103754_sm_miscellaneous_information.pdf1.1 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume50, Issue41October 4, 2011Pages 9611-9614 RelatedInformation
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