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In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity

2005; Oxford University Press; Volume: 26; Issue: 20 Linguagem: Inglês

10.1093/eurheartj/ehi461

1522-9645

Rob Krams, Stefan Verheye, Luc C.A. van Damme, Dennie Tempel, Babak Mousavi Gourabi, Eric Boersma, Mark Kockx, Michiel Knaapen, Chaylendra Strijder, Glenn Van Langenhove, Gerard Pasterkamp, Anton F. W. van der Steen, Patrick W. Serruys,

Peptidase Inhibition and Analysis

Aims Plaque rupture has been associated with a high matrix metalloproteinase (MMP) activity. Recently, regional temperature variations have been observed in atherosclerotic plaques in vivo and ascribed to the presence of macrophages. As macrophages are a major source of MMPs, we examined whether regional temperature changes are related to local MMP activity and macrophage accumulation.