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BIBTEX RIS

Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis -Induced Cutaneous Leishmaniasis in Rhesus Macaques ( Macaca mulatta )

2009; American Society for Microbiology; Volume: 54; Issue: 1 Linguagem: Inglês

10.1128/aac.00858-09

ISSN

1098-6596

Autores

Gabriel Grimaldi, Renato Porrozzi, Karen Friedrich, Antônio Têva, Renato Sérgio Marchevsky, Flávia A. Vieira, Norbert Miekeley, Francisco José Roma Paumgartten,

Tópico(s)

Trypanosoma species research and implications

Resumo

ABSTRACT This study compared the efficacies of two N -methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis -induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.

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