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Rapid three‐dimensional T1‐weighted MR imaging with the MP‐RAGE sequence

1991; Wiley; Volume: 1; Issue: 5 Linguagem: Inglês

10.1002/jmri.1880010509

1522-2586

John P. Mugler, James R. Brookeman,

NMR spectroscopy and applications

Abstract The authors investigated the application of three‐dimensional (3D) magnetization‐prepared rapid gradient‐echo (MP‐RAGE) imaging to the acquisition of small (32 × 128 × 256) T1‐weighted 3D data sets with imaging times of approximately 1 minute. A theoretical model was used to study the contrast behavior of brain tissue. On the basis of these theoretical results, 3D MP‐RAGE sequences were implemented on a 1.5‐T whole‐body imager. Thirty‐two‐section 3D data sets demonstrating good signal‐to‐noise ratios and resolution and strong T1‐weighted contrast were obtained in 1 minute. Compared with standard short TR/TE spin‐echo sequences with the same imaging times and comparable sequence parameters, the 3D MP‐RAGE sequence delivered increases of more than 50% in the white matter/gray matter signal difference‐to‐noise and white matter signal‐to‐noise ratios, and provided almost twice as many sections. These sequences may find a clinical role in 3D scout imaging and screening and in patients with claustrophobia or trauma.